BAPTA AM
BAPTA-AM
CAS: 126150-97-8
Molecular Formula: C34H40N2O18
BAPTA AM - Names and Identifiers
BAPTA AM - Physico-chemical Properties
| Molecular Formula | C34H40N2O18 |
| Molar Mass | 764.68 |
| Density | 1.350±0.06 g/cm3(Predicted) |
| Melting Point | 86-90°C |
| Boling Point | 796.1±60.0 °C(Predicted) |
| Solubility | Soluble in chloroform, dimethyl sulfoxide |
| Appearance | powder |
| Color | White |
| Maximum wavelength(λmax) | 287 nm |
| BRN | 7458534 |
| pKa | 1.69±0.50(Predicted) |
| Storage Condition | -20°C |
| Stability | Light Sensitive |
| Sensitive | Sensitive to heat |
| MDL | MFCD00036696 |
| Use | A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2 stores. |
| In vitro study | BAPTA-AM, as an intracellular calcium chelator, delayed necrosis was induced by lipoxygenase-mediated free radicals in mouse cortical medium. In HEK 293 cells, BAPTA-AM showed Open Channel blockade of hERG,hKv1.3 and hKv1.5 channels with IC50 of 1.3,1.45 and 1.23 μm. |
| In vivo study | In BDL rats, BAPTA-AM abrogated either UDCA-and TUDCA-induced increases in Ca2 levels or Ca2-dependent phosphorylation of PKC-α, and counteracts the cytoprotective effect of UDCA and TUDCA on biliary vagotomy-induced injury. |
BAPTA AM - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-21 |
BAPTA AM - Introduction
maximum wavelength (& lambda;max) 287 nm
indicators of applied Calcium in biological field; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions
Cell permeability chelating agent BAPTA-AM is a cell permeability chelating agent. The selectivity for Ca2 + exceeds Mg2 + and can be used to control intracellular Ca2 + levels. The selectivity of BAPTA for Ca2 + is stronger than that of EDTA and EGTA, and its metal chelation is relatively less sensitive to pH.
Biological activity
the BAPTA-AM is to select the permeable membrane calcium chelating agent.
In vitro study
BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis through free radicals mediated by lipoxygenase in mouse cortical medium. In HEK 293 cells, BAPTA-AM showed an open channel blocking effect on hERG,hKv1.3 and hKv1.5 channels with IC50 of 1.3,1.45 and 1.23 μM.
In vivo studies
In BDL rats, UDCA-and TUDCA-induced increases in Ca2 + levels or Ca2 +-dependent PKC-α phosphorylation were BAPTA-AM abolished, and the cytoprotective effects of UDCA and TUDCA on injuries induced by biliary vagotomy were counteracted.
Target
Ca 2 chelator
IC50: 1.3 μM (hERG channel, in HEK 293 cells), 1.45 μM (hKv1.3, in HEK 293 cells), 1.23 μM (hKv1.5, in HEK 293 cells)
Last Update：2024-04-10 22:29:15
BAPTA AM - Reference Information
| cell permeability chelating agent | BAPTA-AM is a cell permeability chelating agent whose selectivity for Ca2 exceeds Mg2 and can be used to control intracellular Ca2 levels. The selectivity of BAPTA for Ca2 + is stronger than that of EDTA and EGTA, and its metal chelation is relatively less sensitive to pH. |
| biological activity | BAPTA-AM is to select a permeable membrane calcium chelating agent. |
| In vitro studies | BAPTA-AM, as an intracellular calcium chelator, in mouse cortex culture media through lipoxygenase-mediated free radicals induce delayed necrosis. In HEK 293 cells, BAPTA-AM showed an open channel blocking effect on hERG,hKv1.3 and hKv1.5 channels with IC50 of 1.3,1.45 and 1.23 μM. |
| In vivo studies | In BDL rats, UDCA-and TUDCA-induced increases in Ca2 levels or Ca2 +-dependent PKC-α phosphorylation were BAPTA-AM abolished, and the cytoprotective effects of UDCA and TUDCA on injuries induced by biliary vagotomy were counteracted. |
| target | Ca 2 chelator IC50: 1.3 μ m (hERG channel, in HEK 293 cells), 1.45 μ m (hkv1.3, in HEK 293 cells), 1.23 μ m (hkv1.5, in HEK 293 cells) |
| biological field application | Calcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions |
Last Update：2024-04-09 21:04:16
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Spot supply
Product Name: BAPTA-AM Visit Supplier Webpage Request for quotationCAS: 126150-97-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: BAPTA-AM Visit Supplier Webpage Request for quotationCAS: 126150-97-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: BAPTA-AM Visit Supplier Webpage Request for quotationCAS: 126150-97-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BAPTA-AM Visit Supplier Webpage Request for quotationCAS: 126150-97-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: BAPTA-AM Visit Supplier Webpage Request for quotationCAS: 126150-97-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
BAPTA AM
人参皂甙Re
BETA-BENZOYLPROPIONIC ACID
2-CHLORO-5-NITROPYRIMIDINE
Benzenamine, N-[(2-chloro-5-nitrophenyl)methylene]-3,5-dimethyl-
Sodium Perborate Anhydrous
Febuxostat
2-Fluoro-3-(trifluoromethoxy)phenacyl bromide
Cyclohexene oxide
4-FLUORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID
人参皂甙Re
BETA-BENZOYLPROPIONIC ACID
2-CHLORO-5-NITROPYRIMIDINE
Benzenamine, N-[(2-chloro-5-nitrophenyl)methylene]-3,5-dimethyl-
Sodium Perborate Anhydrous
Febuxostat
2-Fluoro-3-(trifluoromethoxy)phenacyl bromide
Cyclohexene oxide
4-FLUORO-3-(TRIFLUOROMETHYL)CINNAMIC ACID